Hexagonal layouts create several neighbor directions, so a placement affects more nearby routes than a simple row-and-column view suggests. Look for pieces that fit only one region and leave those spaces available until you need them.
In Hex Puzzle, avoid creating small isolated pockets that no upcoming piece can fill. Compare a quick clear with the shape of the remaining empty board. If a run gets stuck, identify the placement that first divided the open area into unusable fragments.
The best move depends on the piece rules, so test a pattern across several boards.